Article
Defining potentially conserved RNA regulons of homologous zinc-finger RNA-binding proteins.
Genome biology - 1 Jan 2011
Scherrer Tanja, Femmer Christian, Schiess Ralph, Aebersold Ruedi, Gerber André P
Abstract excerpt
BACKGROUND: Glucose inhibition of gluconeogenic growth suppressor 2 protein (Gis2p) and zinc-finger protein 9 (ZNF9) are conserved yeast and human zinc-finger proteins. The function of yeast Gis2p is unknown, but human ZNF9 has been reported to bind nucleic acids, and mutations in the ZNF9 gene cause the neuromuscular disease myotonic dystrophy type 2. To explore the impact of these proteins on RNA regulation, we...
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