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Article

Drug repositioning for orphan genetic diseases through Conserved Anticoexpressed Gene Clusters (CAGCs).

BMC bioinformatics - 2 Oct 2013

Molineris Ivan, Ala Ugo, Provero Paolo, Di Cunto Ferdinando

Abstract excerpt

BACKGROUND: The development of new therapies for orphan genetic diseases represents an extremely important medical and social challenge. Drug repositioning, i.e. finding new indications for approved drugs, could be one of the most cost- and time-effective strategies to cope with this problem, at least in a subset of cases. Therefore, many computational approaches based on the analysis of high throughput gene...

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Identifiers

PMID: 24088245
DOI: 10.1186/1471-2105-14-288
PMCID: PMC3851137

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