Article
Methylenetetrahydrofolate reductase C677T polymorphism is associated with estimated glomerular filtration rate in hypertensive Chinese males.
BMC medical genetics - 16 Aug 2012
Dong Qing, Tang Genfu, He Mingli, Cai Yunqing, Cai Yefeng, Xing Houxun, Sun Liming, Li Jianping, Zhang Yan, Fan Fangfang, Wang Binyan, Sun Ningling, Liu Lisheng, Xu Xiping, Hou Fanfan, Shen Hongbing, Xu Xin, Huo Yong
Abstract excerpt
BACKGROUND: Plasma level of total homocysteine (tHcy) is negatively correlated with kidney function in general population. However, the causal mechanism of this correlation is poorly understood. The purpose of this study is to investigate the association of methylenetetrahydrofolate reductase (MTHFR) C677T gene polymorphism, which is a major genetic determinant of the plasma tHcy level, with estimated glomerular...
Topics
- Aged
- Asian People
- Cross-Sectional Studies
- Female
- Genetic Association Studies
- Genetic Predisposition to Disease
- Glomerular Filtration Rate
- Humans
- Hypertension