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Article

The molecular basis of frontotemporal dementia.

Expert reviews in molecular medicine - 29 Jul 2009

Neumann Manuela, Tolnay Markus, Mackenzie Ian R A

Abstract excerpt

Frontotemporal dementia (FTD) is a clinical syndrome with a heterogeneous molecular basis. Familial FTD has been linked to mutations in several genes, including those encoding the microtubule-associated protein tau (MAPT), progranulin (GRN), valosin-containing protein (VCP) and charged multivescicular body protein 2B (CHMP2B). The associated neuropathology is characterised by selective degeneration of the frontal...

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Share to Adenosine Triphosphatases
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 19638255
DOI: 10.1017/S1462399409001136

Genes

GRN
MAPT
VCP

Provenance

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