Article
Normative growth charts for individuals with Costello syndrome.
American journal of medical genetics. Part A - 1 Nov 2012
Sammon Mary R, Doyle Dan, Hopkins Elizabeth, Sol-Church Katia, Stabley Deborah L, McGready John, Schulze Kerry, Alade Yewande, Hoover-Fong Julie, Gripp Karen W
Abstract excerpt
Costello syndrome is a rare condition due to heterozygous germline mutations in the proto-oncogene HRAS. It affects multiple organ systems and includes severe failure-to-thrive, short stature, and macrocephaly. The goal of this study was to develop Costello syndrome-specific growth curves. We collected height, weight, and head circumference (OFC) measurements from 94 individuals (45 males and 49 females). Their...
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