Article
Plasminogen activator inhibitor 1 and methylenetetrahydrofolate reductase gene mutations in iranian women with polycystic ovary syndrome.
American journal of reproductive immunology (New York, N.Y. : 1989) - 1 Nov 2012
Idali Farah, Zareii Said, Mohammad-Zadeh Afsane, Reihany-Sabet Fakhreddin, Akbarzadeh-Pasha Zoreh, Khorram-Khorshid Hamid-Reza, Zarnani Amir-Hassan, Jeddi-Tehrani Mahmood
Abstract excerpt
PROBLEM: Mutations in genes related to thrombophilia and hypofibrinolysis have been associated with recurrent pregnancy loss (RPL) and polycystic ovary syndrome (PCOS). METHODS: Using PCR-RFLP, we investigated the frequencies of MTHFR (A1298C and C677T) as well as PAI-1 (-675 4G/5G) gene polymorphisms in 177 RPL and 100 control women. RPL women were stratified into 38 women with PCOS (RPL-PCOS), 33 with ovarian...
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