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Article

Drug‐induced QT interval prolongation: does ethnicity of the thorough QT study population matter?

8 Aug 2012

Abstract excerpt

Inter-ethnic differences in drug responses have been well documented. Drug-induced QT interval prolongation is a major safety concern and therefore, regulatory authorities recommend a clinical thorough QT study (TQT) to investigate new drugs for their QT-prolonging potential. A positive study, determined by breach of a preset regulatory threshold, significantly influences late phase clinical trials by requiring...

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PMID: 22882246
DOI: 10.1111/j.1365-2125.2012.04415.x

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