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Article

Conformational co-dependence between Plasmodium berghei LCCL proteins promotes complex formation and stability.

Molecular and biochemical parasitology - 1 Oct 2012

Saeed Sadia, Tremp Annie Z, Dessens Johannes T

Abstract excerpt

Malaria parasites express a conserved family of LCCL-lectin adhesive-like domain proteins (LAPs) that have essential functions in sporozoite transmission. In Plasmodium falciparum all six family members are expressed in gametocytes and form a multi-protein complex. Intriguingly, knockout of P. falciparum LCCL proteins adversely affects expression of other family members at protein, but not at mRNA level, a...

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Identifiers

PMID: 22877575
DOI: 10.1016/j.molbiopara.2012.07.007
PMCID: PMC3473356

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