Article
Asunaprevir (BMS-650032) for the treatment of hepatitis C virus.
Expert review of anti-infective therapy - 1 Jan 2015
Akamatsu Nobuhisa, Sugawara Yasuhiko, Kokudo Norihiro
Abstract excerpt
Asunaprevir, a second-generation NS3 protease inhibitor of hepatitis C virus (HCV), exhibits strong antiviral activity against HCV genotypes 1 and 4, but relatively weak activity against genotypes 2 and 3. For chronic HCV infection, asunaprevir with daclatasvir as an interferon-free dual treatment achieves a sustained virologic response of nearly 90% in genotype 1b, and a triple regimen with beclabuvir achieves...
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