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Article

Rapid and sharp decline in HCV upon monotherapy with NS3 protease inhibitor, ACH-1625.

Antiviral therapy - 1 Jan 2012

Agarwal Atul, Zhang Bao, Olek Elizabeth, Robison Heather, Robarge Lisa, Deshpande Milind

Abstract excerpt

BACKGROUND: ACH-1625 is a linear peptidomimetic inhibitor that non-covalently binds to HCV NS3 protease with high potency and specificity. Short-term monotherapy of HCV genotype-1 infection with ACH-1625 was found to be safe and resulted in ≥3.3 log(10) IU/ml mean viral load reduction. These vira...

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Source

Identifiers

PMID: 22976492
DOI: 10.3851/IMP2359

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22976492-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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