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Article

Autoimmune lymphoproliferative syndrome caused by a homozygous null FAS ligand (FASLG) mutation.

The Journal of allergy and clinical immunology - 1 Feb 2013

Magerus-Chatinet Aude, Stolzenberg Marie-Claude, Lanzarotti Nina, Neven Bénédicte, Daussy Cécile, Picard Capucine, Neveux Nathalie, Desai Mukesh, Rao Meghana, Ghosh Kanjaksha, Madkaikar Manisha, Fischer Alain, Rieux-Laucat Frédéric

Abstract excerpt

BACKGROUND: Autoimmune lymphoproliferative syndrome (ALPS) is characterized by chronic nonmalignant lymphoproliferation, accumulation of double-negative T cells, hypergammaglobulinemia G and A, and autoimmune cytopenia. OBJECTIVES: Although mostly associated with FAS mutations, different genetic defects leading to impaired apoptosis have been described in patients with ALPS, including the FAS ligand gene (FASLG)...

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Identifiers

PMID: 22857792
DOI: 10.1016/j.jaci.2012.06.011
PMCID: PMC3824280

Genes

FAS
FASLG

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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