Article
Duplication of CXC chemokine genes on chromosome 4q13 in a melanoma-prone family.
Pigment cell & melanoma research - 1 Mar 2012
Yang Xiaohong R, Brown Kevin, Landi Maria T, Ghiorzo Paola, Badenas Celia, Xu Mai, Hayward Nicholas K, Calista Donato, Landi Giorgio, Bruno William, Bianchi-Scarrà Giovanna, Aguilera Paula, Puig Susana, Goldstein Alisa M, Tucker Margaret A
Abstract excerpt
Copy number variations (CNVs) have been shown to contribute substantially to disease susceptibility in several inherited diseases including cancer. We conducted a genome-wide search for CNVs in blood-derived DNA from 79 individuals (62 melanoma patients and 17 spouse controls) of 30 high-risk melanoma-prone families without known segregating mutations using genome-wide comparative genomic hybridization (CGH)...
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