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Article

Causes of Comorbidity: Pleiotropy or Causality? Shared Genetic and Environmental Influences on Migraine and Neuroticism

28 Mar 2012

Abstract excerpt

Comorbidity - the clustered occurrence of two traits or disorders - may be studied in genetically informative designs such as the classical twin study, to test whether genetic and/or environmental factors underlying the two disorders are correlated. When a genetic correlation is found, this can be explained by several mechanisms, including pleiotropy (the same genes influencing multiple traits), and causality...

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PMID: 22856357
DOI: 10.1375/twin.15.2.158

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