Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The effect of genetic background and dose on non-targeted effects of radiation.

International journal of radiation biology - 1 Oct 2012

Irons Sarah L, Serra Virginia, Bowler Deborah, Chapman Kim, Militi Stefania, Lyng Fiona, Kadhim Munira

Abstract excerpt

PURPOSE: This work investigates the hypothesis that genetic background plays a significant role in the signalling mechanisms underlying induction and perpetuation of genomic instability following radiation exposure. MATERIALS AND METHODS: Bone marrow from two strains of mice (CBA and C57) were exposed to a range of X-ray doses (0, 0.01, 0.1, 1 and 3 Gy). Different cellular signalling endpoints: Apoptosis,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Bone Marrow Cells
Share to Bystander Effect

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Dose-Response Relationship, Radiation

Share to Genomic Instability

Share to Linear Energy Transfer

Share to Radiation Tolerance

Share to Transforming Growth Factor beta

Share to X-Rays

Source

Identifiers

PMID: 22853854
DOI: 10.3109/09553002.2012.715793

Genes

TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The effect of genetic background and dose on non-targeted effects of radiation.PMID 22853854Read ↗

Long-lived Inflammatory Signaling in Irradiated Bone Marrow Is Genome DependentSemantic proximity Read ↗

Genetic differences in transcript responses to low-dose ionizing radiation identify tissue functions associated with breast cancer susceptibility.Semantic proximity Read ↗

Damaging and protective cell signalling in the untargeted effects of ionizing radiation.Semantic proximity Read ↗

Tissue-specific p53 responses to ionizing radiation and their genetic modification: the key to tissue-specific tumour susceptibility?Semantic proximity Read ↗

Susceptibility to radiation-induced leukaemia/lymphoma is genetically separable from sensitivity to radiation-induced genomic instability.Semantic proximity Read ↗

Global Gene Expression Response in Mouse Models of DNA Repair Deficiency after Gamma Irradiation.Semantic proximity Read ↗

In Vivo Bystander Effect: Cranial X-Irradiation Leads to Elevated DNA Damage, Altered Cellular Proliferation and Apoptosis, and Increased p53 Levels in Shielded SpleenSemantic proximity Read ↗

Radiation-induced translocations in mice: persistence, chromosome specificity, and influence of genetic background.Semantic proximity Read ↗

Concurrent low-dose-rate gamma irradiation and inorganic arsenite: genotoxicity and transcriptional responses in liver and testis in CBA and C57BL/6 miceSemantic proximity Read ↗

Radiation-induced apoptosis in mouse lymphocytes is modified by a complex dietary supplement: the effect of genotype and gender.Semantic proximity Read ↗

Interactions of apoptotic cells with macrophages in radiation-induced bystander signaling.Semantic proximity Read ↗

The<i>In Vivo</i>Expression of Radiation-Induced Chromosomal Instability Has an Inflammatory MechanismSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.