Article
Mode of action of GR69153, a novel catechol-substituted cephalosporin, and its interaction with the tonB-dependent iron transport system.
Antimicrobial agents and chemotherapy - 1 Sept 1990
Silley P, Griffiths J W, Monsey D, Harris A M
Abstract excerpt
GR69153 is a novel cephalosporin incorporating a catechol-substituted 7-aminothiazolyl-oxime. The antibiotic is actively transported into gram-negative cells via iron-regulated outer membrane proteins regulated by the tonB product. This transport enhances bactericidal activity most significantly at low concentrations, essentially removing the permeability barrier for antibiotic uptake.
Topics
- Biological Transport
- Carrier Proteins
- Cephalosporins
- Chelating Agents
- Escherichia coli
- Iron
- Iron Chelating Agents
- Magnesium Chloride
- Microbial Sensitivity Tests
- Mutation
- Spectrophotometry