How does adaptation sweep through the genome? Insights from long-term selection experiments.

doi:10.1098/rspb.2012.0799

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Article

How does adaptation sweep through the genome? Insights from long-term selection experiments.

Proceedings. Biological sciences - 22 Dec 2012

Burke Molly K

Abstract excerpt

A major goal in evolutionary biology is to understand the origins and fates of adaptive mutations. Natural selection may act to increase the frequency of de novo beneficial mutations, or those already present in the population as standing genetic variation. These beneficial mutations may ultimately reach fixation in a population, or they may stop increasing in frequency once a particular phenotypic state has been...

Topics

Adaptation, Biological
Animals
Bacteria
Biological Evolution
Caenorhabditis elegans
Drosophila melanogaster
Fungi
Gene Frequency
Genetic Variation
Genome
Genome, Bacterial
Genome, Fungal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome, Insect

Genome-Wide Association Study

Mutation

Reproduction

Saccharomyces cerevisiae

Selection, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 22833271
DOI: 10.1098/rspb.2012.0799
PMCID: PMC3497228

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-22833271-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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