Article
Investigation of polyomaviruses replication in pediatric patients with nephropathy receiving rituximab.
Journal of medical virology - 1 Sept 2012
Delbue Serena, Ferraresso Mariano, Elia Francesca, Belingheri Mirco, Carloni Camilla, Signorini Lucia, Carluccio Silvia, Dallari Simone, Ghio Luciana, Ferrante Pasquale
Abstract excerpt
Rituximab is a chimeric monoclonal antibody reacting with the CD20 antigen on B cells. It has been proposed as treatment for the idiopathic nephrotic syndrome, recurrent idiopathic nephropathy, and focal segmental glomerulosclerosis refractory to steroids. Rituximab influences T-cell immunity and may predispose the patients to opportunistic infections, such as progressive multifocal leukoencephalopathy caused by...
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