Article
gyrA and parC mutations in quinolone-resistant clinical isolates of Pseudomonas aeruginosa from Nini Hospital in north Lebanon.
Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy - 1 Feb 2013
Salma Rayan, Dabboussi Fouad, Kassaa Imad, Khudary Rami, Hamze Monzer
Abstract excerpt
The problem of Pseudomonas aeruginosa resistance to fluoroquinolones is of growing concern in hospitals. The major mechanism of the resistance of this bacterium to fluoroquinolones is the modification of type II topoisomerases (DNA gyrase and topoisomerase IV). In this study, we examined, using the technique of DNA pyrosequencing, mutations in the quinolone resistance-determining regions of the gyrA and parC...
Topics
- Anti-Bacterial Agents
- DNA Gyrase
- DNA Topoisomerase IV
- Drug Resistance, Bacterial
- Fluoroquinolones
- Hospital Mortality
- Hospitals, University
- Humans
- Lebanon
- Length of Stay