Article
BRCA2 variants and cardiovascular disease in a multi-ethnic study.
BMC medical genetics - 18 Jul 2012
Zbuk Kevin, Xie Changchun, Young Robin, Heydarpour Mahyar, Pare Guillaume, Davis A Darlene, Miller Ruby, Lanktree Matthew B, Saleheen Danish, Danesh John, Yusuf Salim, Engert James C, Hegele Robert A, Anand Sonia S
Abstract excerpt
BACKGROUND: Germline mutations of BRCA1/2 are associated with hereditary breast and ovarian cancer. Recent data suggests excess mortality in mutation carriers beyond that conferred by neoplasia, and recent in vivo and in vitro studies suggest a modulatory role for BRCA proteins in endothelial and cardiomyocyte function. We therefore tested the association of BRCA2 variants with clinical cardiovascular disease...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.