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Adult monozygotic twins discordant for intra-uterine growth have indistinguishable genome-wide DNA methylation profiles

25 May 2013

Abstract excerpt

BACKGROUND: Low birth weight is associated with an increased adult metabolic disease risk. It is widely discussed that poor intra-uterine conditions could induce long-lasting epigenetic modifications, leading to systemic changes in regulation of metabolic genes. To address this, we acquire genome-wide DNA methylation profiles from saliva DNA in a unique cohort of 17 monozygotic monochorionic female twins very...

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PMID: 23706164
DOI: 10.1186/gb-2013-14-5-r44

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