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Article

Analysis of neuromuscular junctions and effects of anabolic steroid administration in the SOD1G93A mouse model of ALS.

Molecular and cellular neurosciences - 1 Aug 2012

Cappello Valentina, Vezzoli Elena, Righi Marco, Fossati Matteo, Mariotti Raffaella, Crespi Arianna, Patruno Marco, Bentivoglio Marina, Pietrini Grazia, Francolini Maura

Abstract excerpt

Several lines of evidence indicate that neuromuscular junction (NMJ) destruction and disassembly is an early phenomenon in amyotrophic lateral sclerosis (ALS). Here we analyzed by confocal and electron microscopy the NMJ structure in the diaphragm of SOD1G93A mice at symptom onset. In these mice, which provide a model for familial ALS, diaphragm denervation (~50%) as well as gastrocnemius denervation (~40%) was...

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Source

Identifiers

PMID: 22800606
DOI: 10.1016/j.mcn.2012.07.003

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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