Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Routine sequencing of BRAF exon 15 improves therapeutic stratification for metastatic melanoma.

American journal of clinical pathology - 1 Dec 2025

Chen Yi Fan, Qureshi Arshna, Sigel Jessica E, Sadri Navid

Abstract excerpt

OBJECTIVE: BRAF V600E/K mutations are significant drivers of metastatic melanoma, and therapies that selectively target these mutations have significantly improved patient long-term survival. Emerging evidence suggests that tumors harboring BRAF non-V600E/K mutations are susceptible to MEK-targeting therapies, but these mutations are not always assessed in clinical workup. To assess whether patient stratification...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Aged
Share to Aged, 80 and over
Share to DNA Mutational Analysis

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to High-Throughput Nucleotide Sequencing

Share to Melanoma

Share to Proto-Oncogene Proteins B-raf

Share to Skin Neoplasms

Source

Identifiers

PMID: 41273144
DOI: 10.1093/ajcp/aqaf122

Genes

BRAF

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Routine sequencing of BRAF exon 15 improves therapeutic stratification for metastatic melanoma.PMID 41273144Read ↗

BRAF(L597) mutations in melanoma are associated with sensitivity to MEK inhibitors.Semantic proximity Read ↗

Response to targeted therapy in two patients with metastatic melanoma carrying rare BRAF exon 15 mutations: A598_T599insV and V600_K601delinsE.Semantic proximity Read ↗

The clinical significance of BRAF and NRAS mutations in a clinic-based metastatic melanoma cohort.Semantic proximity Read ↗

Prevalence of exon 15 BRAF mutations in primary melanoma of the superficial spreading, nodular, acral, and lentigo maligna subtypes.Semantic proximity Read ↗

Non-p.V600E BRAF Mutations Are Common Using a More Sensitive and Broad Detection ToolSemantic proximity Read ↗

Analysis of BRAF and N-RAS mutations in metastatic melanoma tissues.Semantic proximity Read ↗

Comparison of targeted next generation sequencing (NGS) versus isolated BRAF V600E analysis in patients with metastatic melanoma.Semantic proximity Read ↗

Comparison of Five Different Assays for the Detection of BRAF Mutations in Formalin-Fixed Paraffin Embedded Tissues of Patients with Metastatic Melanoma.Semantic proximity Read ↗

B-raf exon 15 mutations are common in primary melanoma resection specimens but not associated with clinical outcome.Semantic proximity Read ↗

Exclusion of BRAFV599E as a melanoma susceptibility mutation.Semantic proximity Read ↗

Routine Multiplex Mutational Profiling of Melanomas Enables Enrollment in Genotype-Driven Therapeutic TrialsSemantic proximity Read ↗

Comparison of high resolution melting analysis, pyrosequencing, next generation sequencing and immunohistochemistry to conventional Sanger sequencing for the detection of p.V600E and non-p.V600E BRAF mutations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.