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Article

Genetic determinants of right-ventricular remodeling after tetralogy of Fallot repair.

Pediatric research - 1 Oct 2012

Jeewa Aamir, Manickaraj Ashok Kumar, Mertens Luc, Manlhiot Cedric, Kinnear Caroline, Mondal Tapas, Smythe John, Rosenberg Herschel, Lougheed Jane, McCrindle Brian W, van Arsdell Glen, Redington Andrew N, Mital Seema

Abstract excerpt

BACKGROUND: Hypoxia-inducible factor (HIF1A) regulates the myocardial response to hypoxia and hemodynamic load. We investigated the association of HIF1A variants with right-ventricular (RV) remodeling after tetralogy of Fallot (TOF) repair. METHODS: Children with TOF were genotyped for three single-nucleotide polymorphisms in HIF1A. Genotypes were analyzed for association with RV myocardial protein expression and...

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Identifiers

PMID: 22797143
DOI: 10.1038/pr.2012.95

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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