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Article

Patients with repaired tetralogy of Fallot and the HIF1A1744C/T variant have increased imaging markers of diffuse myocardial fibrosis.

International journal of cardiology - 1 Mar 2022

Vaikom House Aswathy K, Chetan Devin, Mital Seema, Grosse-Wortmann Lars

Abstract excerpt

BACKGROUND: Right ventricular fibrotic remodeling has been identified pre- and postoperatively in patients with tetralogy of Fallot (ToF) and linked to adverse outcomes. Polymorphisms of hypoxia inducible factor-1-alpha (HIF1A) have been associated with the fibrotic burden by cardiac magnetic resonance (CMR) late gadolinium enhancement imaging. Their association with diffuse fibrotic myocardial remodeling is...

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Identifiers

PMID: 34973973
DOI: 10.1016/j.ijcard.2021.12.047

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