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Article

Pathobiologic mechanisms of chronic obstructive pulmonary disease.

The Medical clinics of North America - 1 Jul 2012

Tam Anthony, Sin Don D

Abstract excerpt

COPD is a worldwide public health problem that reduces the quality of life. The exact pathways by which CS and other environmental toxins produce COPD are not known. Currently, the leading candidates are (1) the protease-antiprotease hypothesis, (2) the Dutch hypothesis, (3) the British hypothesis, and the (4) autoimmunity hypothesis. Given the heterogeneity of the disease (and phenotypes), it is probably...

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Identifiers

PMID: 22793938
DOI: 10.1016/j.mcna.2012.04.012

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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