Article
[The genetics of chronic obstructive pulmonary disease].
Pneumologie (Stuttgart, Germany) - 1 Jan 2009
Arinir U, Hoffjan S, Knoop H, Schultze-Werninghaus G, Epplen J T, Rohde G
Abstract excerpt
COPD is a heterogenous disease caused by the interaction of genetic susceptibility and environmental influences. The best example to support this is tobacco smoke. Although cigarette smoking is the most important aetiological factor, only up to half of chronic smokers develop significant COPD. There are three main themes within the pathogenesis of COPD: 1) imbalance between proteases and anti-proteases, 2)...
Topics
- Enzymes
- Genetic Predisposition to Disease
- Genetic Variation
- Glutathione Transferase
- Humans
- Inflammation
- Matrix Metalloproteinases
- Oxidative Stress
- Peptide Hydrolases
- Proteins
- Pulmonary Disease, Chronic Obstructive