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Article

Plasma clearance of hemoglobin and haptoglobin in mice and effect of CD163 gene targeting disruption.

Antioxidants & redox signaling - 10 Jun 2013

Etzerodt Anders, Kjolby Mads, Nielsen Marianne Jensby, Maniecki Maciej, Svendsen Pia, Moestrup Søren Kragh

Abstract excerpt

AIM: In humans, plasma haptoglobin (Hp) and the macrophage receptor CD163 promote a fast scavenging of hemoglobin (Hb). In the present study, we have compared the mouse and human CD163-mediated binding and uptake of Hb and HpHb complex in vitro and characterized the CD163-mediated plasma clearance of Hb in CD163 gene knockout mice and controls. RESULTS: Contrary to human Hp, mouse Hp did not promote high-affinity...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 22793784
DOI: 10.1089/ars.2012.4605

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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