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Article

Emerging targeted therapies in myelofibrosis.

Expert review of hematology - 1 Jun 2012

Barosi Giovanni

Abstract excerpt

Conventional drugs for myelofibrosis are driven by clinical needs, primarily anemia and splenomegaly. With these therapies, stem cell transplantation remains the only potentially curative approach. The discovery that mutations affecting JAK2 or MPL lead to activation of the intracellular JAK-STAT signaling pathway, and that other mutations (TET2, EZH2, ASXL1, IDH1 and IDH2) interfere with the normal machinery of...

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Topics

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Share to Gene Expression Regulation, Neoplastic
Share to Janus Kinase 2
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Primary Myelofibrosis

Share to Protein Kinase Inhibitors

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Share to TOR Serine-Threonine Kinases

Source

Identifiers

PMID: 22780211
DOI: 10.1586/ehm.12.17

Genes

JAK2
ASXL1
IDH1
IDH2
MPL
TET2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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