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Article

Contribution of major amyotrophic lateral sclerosis genes to the etiology of sporadic disease.

Neurology - 3 Jul 2012

Lattante Serena, Conte Amelia, Zollino Marcella, Luigetti Marco, Del Grande Alessandra, Marangi Giuseppe, Romano Angela, Marcaccio Alessandro, Meleo Emiliana, Bisogni Giulia, Rossini Paolo Maria, Sabatelli Mario

Abstract excerpt

OBJECTIVES: To quantify the overall contribution of mutations in the currently known amyotrophic lateral sclerosis (ALS) genes in a large cohort of sporadic patients and to make genotype-phenotype correlations. METHODS: Screening for SOD1, TARDBP, FUS, ANG, ATXN2, OPTN, and C9ORF72 was carried out in 480 consecutive patients with sporadic ALS (SALS) and in 48 familial ALS (FALS) index patients admitted to a...

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Source

Identifiers

PMID: 22722621
DOI: 10.1212/WNL.0b013e31825dceca

Genes

SOD1
TARDBP
ANG
ATXN2
FUS
OPTN

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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