Article
Oxidative stress contributes to outcome severity in a Drosophila melanogaster model of classic galactosemia.
Disease models & mechanisms - 1 Jan 2013
Jumbo-Lucioni Patricia P, Hopson Marquise L, Hang Darwin, Liang Yongliang, Jones Dean P, Fridovich-Keil Judith L
Abstract excerpt
Classic galactosemia is a genetic disorder that results from profound loss of galactose-1P-uridylyltransferase (GALT). Affected infants experience a rapid escalation of potentially lethal acute symptoms following exposure to milk. Dietary restriction of galactose prevents or resolves the acute sequelae; however, many patients experience profound long-term complications. Despite decades of research, the mechanisms...
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