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Article

Epigenetic regulation of the neuroblastoma genes, Arid3b and Mycn

2 Jul 2012

Abstract excerpt

AT-rich interaction domain molecule 3B (ARID3B) and MYCN are expressed in a portion of neuroblastoma, and form a combination that has strong oncogenic activity in mouse embryonic fibroblasts (MEFs). Here, we show that this combination can also convert neural stem cells to neuroblastoma-like tumor. To address whether there are common mechanisms regulating the expression of this combination of genes, we examined...

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PMID: 22751132
DOI: 10.1038/onc.2012.285

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