Article
Immunophenotypical analysis of myofibroblasts and mesenchymal cells in the bleomycin-induced rat scleroderma, with particular reference to their origin.
Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie - 1 Jul 2013
Juniantito Vetnizah, Izawa Takeshi, Yuasa Takahiro, Ichikawa Chisa, Tanaka Miyuu, Kuwamura Mitsuru, Yamate Jyoji
Abstract excerpt
Cellular characteristics of myofibroblasts and its possible origin with mesenchymal stem cell nature in scleroderma remain to be investigated. We analyzed these cells in scleroderma induced in F344 rats by bleomycin (BLM) by immunolabeling using a panel of marker antibodies for cytoskeletons (vimentin, desmin, α-smooth muscle actin (α-SMA)) and stromal stem cells (Thy-1, A3). Skin samples were collected at 1, 2,...
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