Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The Zinc Finger Gene ZIC2 Has Features of an Oncogene and Its Overexpression Correlates Strongly with the Clinical Course of Epithelial Ovarian Cancer

26 Jun 2012

Abstract excerpt

PURPOSE: Epithelial ovarian tumors (EOT) are among the most lethal of malignancies in women. We have previously identified ZIC2 as expressed at a higher level in samples of a malignant form (MAL) of EOT than in samples of a form with low malignant potential (LMP). We have now investigated the role of ZIC2 in driving tumor growth and its association with clinical outcomes. EXPERIMENTAL DESIGN: ZIC2 expression...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Adhesion Molecules Research
Share to Developmental Biology and Gene Regulation
Share to Hedgehog Signaling Pathway Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 22733541
DOI: 10.1158/1078-0432.ccr-12-0037

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The Zinc Finger Gene ZIC2 Has Features of an Oncogene and Its Overexpression Correlates Strongly with the Clinical Course of Epithelial Ovarian CancerPMID 22733541Read ↗

Transcription factor ZIC2 regulates the tumorigenic phenotypes associated with both bulk and cancer stem cells in epithelial ovarian cancer.Semantic proximity Read ↗

Zic Family Member 2 (ZIC2): a Potential Diagnostic and Prognostic Biomarker for Pan-CancerSemantic proximity Read ↗

ZIC2 is downregulated and represses tumor growth via the regulation of STAT3 in breast cancerSemantic proximity Read ↗

Zic2 synergistically enhances Hedgehog signalling through nuclear retention of Gli1 in cervical cancer cellsSemantic proximity Read ↗

Analysis of the role of Frizzled 2 in different cancer types.Semantic proximity Read ↗

ZIC2 promotes colorectal cancer growth and metastasis through the TGF-β signaling pathwaySemantic proximity Read ↗

The clinical significance of Zinc finger protein 2 in laryngeal squamous cell carcinoma and its potential mechanismSemantic proximity Read ↗

Silencing ZIC2 abrogates tumorigenesis and anoikis resistance of non-small cell lung cancer cells by inhibiting Src/FAK signalingSemantic proximity Read ↗

ZIC2 promotes cancer stem cell traits via up-regulating OCT4 expression in lung adenocarcinoma cellsSemantic proximity Read ↗

Multilevel regulation of Wnt signaling by Zic2 in colon cancer due to mutation of β-cateninSemantic proximity Read ↗

Potential Role of The Upregulation of The Zinc Finger Protein of The Cerebellum 2 In Nasopharyngeal CarcinomaSemantic proximity Read ↗

Cyclin G2 inhibits epithelial-to-mesenchymal transition by disrupting Wnt/β-catenin signalingSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.