Article
Combinational polymorphisms of four DNA repair genes XRCC1, XRCC2, XRCC3, and XRCC4 and their association with oral cancer in Taiwan.
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology - 1 May 2008
Yen Ching-Yu, Liu Shyun-Yeu, Chen Chung-Ho, Tseng Hung-Fu, Chuang Li-Yeh, Yang Cheng-Hong, Lin Ying-Chu, Wen Cheng-Hao, Chiang Wei-Fan, Ho Chang-Hsuan, Chen Hsiang-Chi, Wang Shaio-Ting, Lin Cheng-Wen, Chang Hsueh-Wei
Abstract excerpt
BACKGROUND: Many single nucleotide polymorphisms (SNPs) have been found to be associated with oral cancer but the biological interactions through SNPs are seldom addressed. In this study, we focused on the joint effect for SNP combinations of four DNA repair genes, X-ray repair cross-complementing groups (XRCCs) 1-4, involved in major cancer-related pathways. METHODS: Single nucleotide polymorphism genotyping was...
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