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Article

Changes in the composition of cytoskeletal and cytocontractile proteins of rat aortic smooth muscle cells during aging.

Differentiation; research in biological diversity - 1 Sept 1990

Nikkari S T, Koistinaho J, Jaakkola O

Abstract excerpt

Cytoskeletal proteins are used as differentiation markers of vascular smooth muscle cells (SMC). To study possible changes in SMC phenotype during aging, cytoskeletal and cytocontractile proteins were quantified in the aortic intima-medias of 4-, 12-, 30-, and 36-month-old rats by one- and two-dimensional gel electrophoresis. The percentages of myosin and desmin in total protein decreased with age, while those of...

Topics

Aging
Animals
Antigens, Differentiation
Aorta
Cell Differentiation
Cytoskeletal Proteins
Densitometry
Electrophoresis, Polyacrylamide Gel
Immunoblotting
Male
Microscopy, Fluorescence

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Muscle Proteins

Muscle, Smooth, Vascular

Phenotype

Rats

Rats, Inbred Strains

Source

Identifiers

PMID: 2272413
DOI: 10.1111/j.1432-0436.1990.tb00620.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2272413-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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