Article
The potential for respiratory droplet-transmissible A/H5N1 influenza virus to evolve in a mammalian host.
Science (New York, N.Y.) - 22 Jun 2012
Russell Colin A, Fonville Judith M, Brown André E X, Burke David F, Smith David L, James Sarah L, Herfst Sander, van Boheemen Sander, Linster Martin, Schrauwen Eefje J, Katzelnick Leah, Mosterín Ana, Kuiken Thijs, Maher Eileen, Neumann Gabriele, Osterhaus Albert D M E, Kawaoka Yoshihiro, Fouchier Ron A M, Smith Derek J
Abstract excerpt
Avian A/H5N1 influenza viruses pose a pandemic threat. As few as five amino acid substitutions, or four with reassortment, might be sufficient for mammal-to-mammal transmission through respiratory droplets. From surveillance data, we found that two of these substitutions are common in A/H5N1 viruses, and thus, some viruses might require only three additional substitutions to become transmissible via respiratory...
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