Article
H5N1 hybrid viruses bearing 2009/H1N1 virus genes transmit in guinea pigs by respiratory droplet.
Science (New York, N.Y.) - 21 Jun 2013
Zhang Ying, Zhang Qianyi, Kong Huihui, Jiang Yongping, Gao Yuwei, Deng Guohua, Shi Jianzhong, Tian Guobin, Liu Liling, Liu Jinxiong, Guan Yuntao, Bu Zhigao, Chen Hualan
Abstract excerpt
In the past, avian influenza viruses have crossed species barriers to trigger human pandemics by reassorting with mammal-infective viruses in intermediate livestock hosts. H5N1 viruses are able to infect pigs, and some of them have affinity for the mammalian type α-2,6-linked sialic acid airway receptor. Using reverse genetics, we systematically created 127 reassortant viruses between a duck isolate of H5N1,...
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