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Article

Expression of the Zinc-Finger Antiviral Protein Inhibits Alphavirus Replication

13 Oct 2003

Abstract excerpt

The rat zinc-finger antiviral protein (ZAP) was recently identified as a host protein conferring resistance to retroviral infection. We analyzed ZAP's ability to inhibit viruses from other families and found that ZAP potently inhibits the replication of multiple members of the Alphavirus genus within the Togaviridae, including Sindbis virus, Semliki Forest virus, Ross River virus, and Venezuelan equine...

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Identifiers

PMID: 14557641
DOI: 10.1128/jvi.77.21.11555-11562.2003

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