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Article

Escape capture bigeminy: phenotypic marker of cardiac sodium channel voltage sensor mutation R222Q.

Heart rhythm - 1 Oct 2012

Nair Krishnakumar, Pekhletski Roman, Harris Louise, Care Melanie, Morel Chantal, Farid Talha, Backx Peter H, Szabo Elod, Nanthakumar Kumaraswamy

Abstract excerpt

BACKGROUND: Electrocardiographic signature of escape capture bigeminy that spans generations and clusters in a family has not been linked to a sodium channel voltage sensor mutation. OBJECTIVE: To characterize the clinical and biophysical consequences of the R222Q mutation in the voltage sensor of cardiac sodium channels. METHODS: Comprehensive clinical assessment, invasive electrophysiologic study, genetic...

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PMID: 22710484
DOI: 10.1016/j.hrthm.2012.06.029

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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