Article
Associations of genetic variants in the transcriptional coactivators EP300 and PCAF with hepatocellular carcinoma.
Cancer epidemiology - 1 Oct 2012
Akil Abdellah, Ezzikouri Sayeh, El Feydi Abdellah Essaid, Benazzouz Mustapha, Afifi Rajaa, Diagne Ama Gassama, Benjouad Aziz, Dejean Anne, Pineau Pascal, Benjelloun Soumaya
Abstract excerpt
BACKGROUND AND AIMS: Hepatocellular carcinoma (HCC) is a common cause of death by cancer worldwide. In Morocco, HCC is characterized by few mutations and a mild chromosome instability suggesting that epigenetic changes may represent the driving force of tumorigenesis in the region. Recently, three studies looked for an association between EP300 or PCAF polymorphisms and cancer but there is a conspicuous lack of...
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