Article
Prevalence of common HFE and SERPINA1 mutations in patients with hepatocellular carcinoma in a Moroccan population.
Archives of medical research - 1 Feb 2008
Ezzikouri Sayeh, El Feydi Abdellah Essaid, El Kihal Latifa, Afifi Rajae, Benazzouz Mustapha, Hassar Mohammed, Chafik Abdelaziz, Pineau Pascal, Benjelloun Soumaya
Abstract excerpt
BACKGROUND: Hereditary hemochromatosis and SERPINA1 mutation were reported to affect liver functions. Our objective was to estimate the prevalence of HFE and SERPINA1 (formerly known as alpha1-antitrypsin, AAT) mutations and assess their influence on hepatocellular carcinoma development. METHODS: This study included 222 controls and 96 cases with hepatocellular carcinoma. PCR-RFLP was used to characterize S and Z...
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