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Article

Systemic buffers inhibit carcinogenesis in TRAMP mice.

The Journal of urology - 1 Aug 2012

Ibrahim-Hashim Arig, Cornnell Heather H, Abrahams Dominique, Lloyd Mark, Bui Marilyn, Gillies Robert J, Gatenby Robert A

Abstract excerpt

PURPOSE: Hypoxia and acidosis develop in in situ tumors as cellular expansion increases the diffusion distance of substrates and metabolites from blood vessels deep to the basement membrane. Prior studies of breast and cervical cancer revealed that cellular adaptation to microenvironmental hypoxi...

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Identifiers

PMID: 22704445
DOI: 10.1016/j.juro.2012.03.113
PMCID: PMC3694604

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22704445-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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