Article
Pancreatic cancer cells retain the epithelial-related phenotype and modify mitotic spindle microtubules after the administration of ukrain in vitro.
Anti-cancer drugs - 1 Oct 2012
Gagliano Nicoletta, Volpari Tatiana, Clerici Marco, Pettinari Letizia, Barajon Isabella, Portinaro Nicola, Colombo Graziano, Milzani Aldo, Dalle-Donne Isabella, Martinelli Carla
Abstract excerpt
The aim of this study is to characterize the phenotype of pancreatic ductal adenocarcinoma (PDAC) cells in relation to the expression of epithelial-to-mesenchymal transition (EMT) markers and determine whether ukrain, an anticancer drug based on the alkaloids extracted from greater celandine, modulates in vitro the malignant behavior of PDAC cells in order to extend our understanding of its therapeutic potential....
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