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hnRNPA2B1 recognizes RNA virus SFTSV infection through mitochondrial DNA

21 Jul 2025

Abstract excerpt

ABSTRACT The heterogeneous nuclear ribonucleoprotein (hnRNPA2B1, hereafter A2B1) was identified as a novel nuclear DNA sensor that mediates antiviral immunity by recognizing viral DNA in the nucleus. However, it remains largely unclear whether A2B1 could function as a nucleic acid pattern-recognition receptor during cytoplasmic RNA virus infection. Severe fever with thrombocytopenia syndrome virus (SFTSV), which...

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PMID: 40689679
DOI: 10.1128/mbio.01668-25

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