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The first recombinant human coagulation factor VIII of human origin: human cell line and manufacturing characteristics

13 Jun 2012

Abstract excerpt

INTRODUCTION: Since the early 1990s, recombinant human clotting factor VIII (rhFVIII) produced in hamster cells has been available for haemophilia A treatment. However, the post-translational modifications of these proteins are not identical to those of native human FVIII, which may lead to immunogenic reactions and the development of inhibitors against rhFVIII. For the first time, rhFVIII produced in a human...

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PMID: 22690791
DOI: 10.1111/j.1600-0609.2012.01804.x

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