Article
Fungal fludioxonil sensitivity is diminished by a constitutively active form of the group III histidine kinase.
FEBS letters - 30 Jul 2012
Furukawa Kentaro, Randhawa Anmoldeep, Kaur Harsimran, Mondal Alok K, Hohmann Stefan
Abstract excerpt
The fungicide fludioxonil is used to control plant-pathogenic fungi by causing improper activation of the Hog1-type MAPK. However, the appearance of fludioxonil resistant mutants, mostly caused by mutations in the group III histidine kinases, poses a serious problem. Moreover, such mutations cause also hyperosmotic sensitivity and the underlying mechanism has been elusive for a long time. Using Saccharomyces...
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