Article
The 3' splice site of influenza A segment 7 mRNA can exist in two conformations: a pseudoknot and a hairpin.
PloS one - 1 Jan 2012
Moss Walter N, Dela-Moss Lumbini I, Kierzek Elzbieta, Kierzek Ryszard, Priore Salvatore F, Turner Douglas H
Abstract excerpt
The 3' splice site of influenza A segment 7 is used to produce mRNA for the M2 ion-channel protein, which is critical to the formation of viable influenza virions. Native gel analysis, enzymatic/chemical structure probing, and oligonucleotide binding studies of a 63 nt fragment, containing the 3' splice site, key residues of an SF2/ASF splicing factor binding site, and a polypyrimidine tract, provide evidence for...
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