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Article

Ecto-5'-nucleotidase: a candidate virulence factor in Streptococcus sanguinis experimental endocarditis.

PloS one - 1 Jan 2012

Fan Jingyuan, Zhang Yongshu, Chuang-Smith Olivia N, Frank Kristi L, Guenther Brian D, Kern Marissa, Schlievert Patrick M, Herzberg Mark C

Abstract excerpt

Streptococcus sanguinis is the most common cause of infective endocarditis (IE). Since the molecular basis of virulence of this oral commensal bacterium remains unclear, we searched the genome of S. sanguinis for previously unidentified virulence factors. We identified a cell surface ecto-5'-nucleotidase (Nt5e), as a candidate virulence factor. By colorimetric phosphate assay, we showed that S. sanguinis Nt5e can...

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Identifiers

PMID: 22685551
DOI: 10.1371/journal.pone.0038059
PMCID: PMC3369921

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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