Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Molecular alterations in epidermal growth factor receptors as potential predictors of invasion in complete hydatidiform moles (CHM).

Disease markers - 1 Jan 2012

Jacob Jemima, Balaram Prabha

Abstract excerpt

Molecular alterations in Epidermal growth factor receptor (EGFR) were investigated for the first time in molar placenta using protein expression, activation status, differential amplification status and mutational analysis. Invasive lesions showed upregulation of internal domain and downregulation of external domain with concomitantly high gene amplification and phosphorylation. Mutations distributed across...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Blotting, Western
Share to ErbB Receptors
Share to Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gestational Age

Share to Immunohistochemistry

Share to Phosphorylation

Share to Placenta

Share to Uterine Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 22684234
DOI: 10.3233/DMA-2012-0895
PMCID: PMC3826895

Genes

EGFR
CHM

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 8 closest

Molecular alterations in epidermal growth factor receptors as potential predictors of invasion in complete hydatidiform moles (CHM).PMID 22684234Read ↗

Trophoblast subtype-specific EGFR/ERBB4 expression correlates with cell cycle progression and hyperplasia in complete hydatidiform molesSemantic proximity Read ↗

Intimal Sarcoma with MDM2/CDK4 Amplification and p16 Overexpression: A Review of Histological Features in Primary Tumor and Xenograft, with Immunophenotype and Molecular Profiling.Semantic proximity Read ↗

Clinicopathologic profile of gestational trophoblastic disease.Semantic proximity Read ↗

Accuracy of p57KIP2 compared with genotyping to diagnose complete hydatidiform mole: a systematic review and meta-analysis.Semantic proximity Read ↗

The status of epidermal growth factor receptor in borderline ovarian tumours.Semantic proximity Read ↗

Accuracy of p57KIP2 compared with genotyping for the diagnosis of complete hydatidiform mole: protocol for a systematic review and meta-analysis.Semantic proximity Read ↗

Molecular Basis of Hydatidiform Moles – A Systematic ReviewSemantic proximity Read ↗

Molecular biology of human epidermal receptors, signaling pathways and targeted therapy against cancers: new evidences and old challengesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.