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Article

Interleukin-6 -634G>C genetic polymorphism is associated with prognosis following surgery for advanced thoracic esophageal squamous cell carcinoma.

Digestive surgery - 1 Jan 2012

Motoyama Satoru, Nakatsu Toshinobu, Miura Masatomo, Hinai Yudai, Minamiya Yoshihiro, Ogawa Jun-ichi

Abstract excerpt

OBJECTIVE: Systemic and/or local interleukin-6 (IL-6) reportedly plays an active role in the progression and prognosis of thoracic esophageal squamous cell carcinoma (TESCC). We assessed the associations between IL-6 and IL-6 receptor (IL-6R) genetic polymorphisms, tumoral IL-6 expression and survival rates following surgery. METHODS: The study participants were 63 Japanese patients treated between 2003 and 2008...

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PMID: 22677780
DOI: 10.1159/000336952

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